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4 Ferroptosis in neurodegenerative diseases: mechanistic insights Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation, and mounting evidence suggests its involvement in the pathogenesis of neurodegenerative diseases, including ischemic stroke, PD, AD, and HD (127)

Each reaction contained 0.4 g TMPK or 0.3 g CMPK was incubated at 25 C followed by using Tecan Spark 10 microplate reader to detect the change in NADH measurement at 340 nm absorption according to the manufacturers instructions

Figure 4 4.2.1 Mechanisms of neuronal ferroptosis after intracerebral hemorrhage Due to the presence of the bloodbrain barrier (BBB), iron entry into the brain is tightly regulated

In cultured femoral VSMCs, a high concentration MGO treatment reduces DNA synthesis, cell viability, cell migration, and MGO-glycation of platelet-derived growth factor receptor (PDGFR) leading to reduced PDGFR signaling [106]